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KMID : 0359819930220121295
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Journal of Korean Neurosurgical Society
1993 Volume.22 No. 12 p.1295 ~ p.1303
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A Comparative Study of BUdR, AgNOR's, and PCNA in Benign and Malignant Astrocytoma
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이원창
신문수/정남/허승곤/이해경
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Abstract
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In 14 cases of astocytoma, we performed a comparative study of BUdR, AgNOR's, and PCNA with histopathology. Fourteen astrocytomas were classified histopathologically into low grade, anaplastic, and G. M. (glioblastoma multiforme) groups. These
comprised
3 G. M., 5 anaplastic astrocytomas. And 6 low grade astrocytomas.
The mean BUdR-LI (Labeling Index) was statisticaliy different (P<0.005) between G. M. (10.4), anaplastic astrocytoma (3.6), and low grade astrocytoma (1.3). On the baiss of correlation between BUdR-LI and histopathology which was reported in 1989
at
PMC, we examined the relationship between BUdR-LI and AgNOR's count, and between BUdR-LI and PCNA-LI, Both AgNOR's count and PCNA-LI did not correlate with BUdR-LI, and also not with histopathology.
This study indicated that, at present, for prognosis and differentiation between malignant and benign astrocytoma, histopathiogy and BUdR-LI are important.
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KEYWORD
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